Background:
@EN Acantholysis can be seen occasionally in the cutaneous squamous cell carcinoma(SCC) as a result of degenerative changes of neoplastic cells.
@ES Objective:
@EN This study was done to investigate the keratin pattern and a wide range of immunohistochemical features of acantholytic ells of cutaneous SCC.
@ES Methods:
@EN Seventeen cases of SCC showed acantholytic cells histologically and formalin-fixed, paraffin-embedded biopsy specimens from them were stained by ABC(avidin-biotin-peroxidase complex) staining. Fourteen biopsy specimens from 14 cases of SCC
were
stained with 3 monoclonal anti-keratin antibodies(CAM 5.2, MAK-6, and 34βE12) and 17 biopsy specimens from 17 cases of SCC were stained with antibodies against CEA( carcinoembryonic antigen), vimentin, S-100 protein, Factor VIIIR Ag, LCA
(leukocyte
common antigen), and lysozyme.
@ES Result & Conclusion:
@EN Acantholytic cells of 14 cases of SCC showed consistently negative staining with CAM 5.2. The acatholytic cells showed a wide range of reactivity with MAK-6 from negative to moderately strong positivity and with 34βE12 from negative to
strong
positivity. A few acantholytic cells of 6 cases of SCC showed weakly positive staining with anti-CEA antibody, but acantholytic cells of all 17 cases showed consistently negative staining with the other antibodies. (Kor J Dermatol 1994 ; 32(4) :
669~674)
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